A natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum; directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf activation associated with vesicular transport (IC50 = ~10 μM)

Brefeldin A – 25 mg

Brand:
Cayman
CAS:
20350-15-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Brefeldin A (BFA) is a natural fungal metabolite which has been used extensively to study intracellular transport by vesicles or endosomes. Early studies demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum.{21254,21256,21248} BFA directly and reversibly inhibits Sec7 domain-containing guanine-exchange factors which are necessary for ADP-ribosylation factor activation associated with vesicular transport (IC50 = ~10 μM).{21253,21252,21247} BFA is used to study endosomal trafficking and function in cells of plants as well as those of fungi, invertebrates, and vertebrates.{21250,21251}  

 

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SKU: 11861 - 25 mg Category:

Description

A natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum; directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf activation associated with vesicular transport (IC50 = ~10 μM)

Formal name: (1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one

Synonyms:  Ascotoxin|BFA|Cyanein|Decumbin|Nectrolide|NSC 107456|NSC 244390|NSC 56310|NSC 89671|Synergisidin

Molecular weight: 280.4

CAS: 20350-15-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking

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