An inhibitor of EHMT2/G9a in enzyme assays (IC50 = 6.3 µM); inhibits PRC2 to a similar extent with 54 and 43% activity remaining for G9a and PRC2

BRD9539 – 1 mg

Brand:
Cayman
CAS:
1374601-41-8
Storage:
-20
UN-No:
Non-Hazardous - /

BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 µM.{20922} It inhibits polycomb repressive complex 2 (PRC2) to a similar extent with 54 and 43% activity remaining for G9a and PRC2, respectively, when used at a concentration of 10 µM. It is selective for G9a and PRC2 over SU39H1 and NDMT1 up to a concentration of 40 µM. It is more potent than BRD4770 (Item No. 11787) in enzyme assays but has no activity in cell-based assays when used at concentrations of 5 and 10 µM.  

 

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SKU: 11788 - 1 mg Category:

Description

An inhibitor of EHMT2/G9a in enzyme assays (IC50 = 6.3 µM); inhibits PRC2 to a similar extent with 54 and 43% activity remaining for G9a and PRC2, respectively (10 µM); has no activity in cell-based assays (5 and 10 µM),

Formal name: 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid

Synonyms: 

Molecular weight: 399.4

CAS: 1374601-41-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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