A dual inhibitor of HDAC6 and HDAC8 (IC50s = 36 and 120 nM

BRD73954 – 5 mg

Brand:
Cayman
CAS:
1440209-96-0
Storage:
-20
UN-No:
Non-Hazardous - /

BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC50s = 36 and 120 nM, respectively).{27579} It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 µM, respectively). BRD73954 (10 µM) increases acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, -2, and -3, in HeLa cells.  

 

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Description

A dual inhibitor of HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively); selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 µM, respectively); increases acetylation of α-tubulin in HeLa cells at 10 µM

Formal name: N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide

Synonyms: 

Molecular weight: 284.3

CAS: 1440209-96-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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