An inhibitor of RSKs (IC50s = 1.5

BRD7389 – 10 mg

Brand:
Cayman
CAS:
376382-11-5
Storage:
-20
UN-No:
Non-Hazardous - /

BRD7389 is an inhibitor of ribosomal S6 kinases (RSKs; IC50s = 1.5, 2.4, and 1.2 μM for RSK1, RSK2, and RSK3, respectively).{33807} Through this action, BRD7389 causes mouse αTC1 pancreatic α cells to adopt several morphological and gene expression features of β cells, including increased insulin expression.{33807} BRD7389 also enhances glucose-stimulated insulin and glucagon secretion by pancreatic islet cells isolated from human donors with a low body mass index.{33807}  

 

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SKU: 20214 - Category:

Description

An inhibitor of RSKs (IC50s = 1.5, 2.4, and 1.2 μM for RSK1, RSK2, and RSK3, respectively); causes mouse αTC1 pancreatic α cells to adopt several morphological and gene expression features of β cells, including increased insulin expression

Formal name: 1-[(2-phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione

Synonyms: 

Molecular weight: 366.4

CAS: 376382-11-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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