An HDAC inhibitor (IC50s = 21 nM

BRD6688 – 5 mg

Brand:
Cayman
CAS:
1404562-17-9
Storage:
-20
UN-No:
Non-Hazardous - /

BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 µM for HDAC1, 2, and 3, respectively.{32059} It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1 (381 min versus 65 min).{32059} BRD6688 crosses the blood brain barrier and has been shown to rescue the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration.{32059}  

 

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Description

An HDAC inhibitor (IC50s = 21 nM, 100 nM, and 11.48 µM for HDAC1, 2, and 3, respectively); possesses six6-fold extended half-life for binding on HDAC2 compared to HDAC1 (381 min vs. 65 min); rescues the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration

Formal name: N-[2-amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide

Synonyms: 

Molecular weight: 282.3

CAS: 1404562-17-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders

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