An HDAC inhibitor (IC50s = 29 nM

BRD4884 – 5 mg

Brand:
Cayman
CAS:
1404559-91-6
Storage:
-20
UN-No:
Non-Hazardous - /

BRD4884 is an HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 µM for HDAC1, 2, and 3, respectively.{32059} It possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min versus 20 min).{32059} BRD4884 crosses the blood brain barrier and has been evaluated in CK-p25 mice, a mouse model of neurodegeneration.{32059}  

 

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Description

An HDAC inhibitor (IC50s = 29 nM, 62 nM, and 1.09 µM for HDAC1, 2, and 3, respectively); possesses preferential binding kinetics with seven-fold longer half-life on HDAC2 compared to HDAC1 (143 min vs. 20 min)

Formal name: N-(4-amino-4′-fluoro[1,1′-biphenyl]-3-yl)tetrahydro-2H-pyran-4-carboxamide

Synonyms: 

Molecular weight: 314.4

CAS: 1404559-91-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Neuroscience|Neurodegenerative Disorders

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