An inhibitor of EHMT2

BRD4770 – 1 mg

Brand:
Cayman
CAS:
1374601-40-7
Storage:
-20
UN-No:
Non-Hazardous - /

BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 µM).{20922} Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis.{20922} It also blocks both anchorage-dependent and –independent proliferation of PANC-1 cells.{20922}  

 

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SKU: 11787 - 1 mg Category:

Description

An inhibitor of EHMT2, also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 µM); induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis

Formal name: 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid, methyl ester

Synonyms:  HMTase Inhibitor VI

Molecular weight: 413.5

CAS: 1374601-40-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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