A phytoalexin from B. campestris that has anticancer

Brassinin – 1 mg

Brand:
Cayman
CAS:
105748-59-2
Storage:
-20
UN-No:
Non-Hazardous - /

Brassinin (BSN) is a phytoalexin isolated from B. campestris that exhibits anticancer, chemopreventative, antiproliferative, and antifungal activities.{38040,38042} Brassinin suppresses constitutive and IL-6-induced STAT3 activation in vitro and attenuates tumor growth in a xenograft lung cancer mouse model through modulation of E3 SUMO-protein ligase 3 (PIAS-3) and suppressor of cytokine signaling-3 (SOCS-3).{38041} Brassinin also induces apoptosis in PC3 cells through suppression of PI3K, Akt, mTOR, and S6K1.{38040}  

 

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Description

A phytoalexin from B. campestris that has anticancer, chemopreventative, antiproliferative, and antifungal activities; supresses constitutive and IL-6-induced STAT3 activation in vitro; attenuates tumor growth in a xenograft lung cancer mouse model through modulation of PIAS-3 and SOCS-3; induces apoptosis in PC3 cells through suppression of PI3K, Akt, mTOR, and S6K1 ,

Formal name: N-(1H-indol-3-ylmethyl)-carbamodithioic acid, methyl ester

Synonyms:  BSN

Molecular weight: 236.4

CAS: 105748-59-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Plant Biology|Plant Defense

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