A phytosterol; inhibits recombinant sterol Δ24-reductase (Ki = 42.7 μM) in vitro; increases accumulation of desmosterol and inhibits cholesterol formation in HL-60 cells in a dose-dependent manner; inhibits the hemolytic activity of pneumolysin from S. pneumoniae

Brassicasterol – 1 mg

Brand:
Cayman
CAS:
474-67-9
Storage:
-20
UN-No:
Non-Hazardous - /

Brassicasterol is a phytosterol found in canola and rapeseed oils, marine algae, and shellfish.{38219} It inhibits recombinant sterol Δ24-reductase with a Ki value of 42.7 μM in vitro. Brassicasterol increases accumulation of desmosterol, a cholesterol precursor and substrate of sterol Δ24-reductase, and inhibits cholesterol formation in HL-60 cells in a dose-dependent manner. It also inhibits the hemolytic activity of pneumolysin from S. pneumoniae without affecting bacterial growth at concentrations up to 1,000 μg/ml.{38220}  

 

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Description

A phytosterol; inhibits recombinant sterol Δ24-reductase (Ki = 42.7 μM) in vitro; increases accumulation of desmosterol and inhibits cholesterol formation in HL-60 cells in a dose-dependent manner; inhibits the hemolytic activity of pneumolysin from S. pneumoniae

Formal name: ergosta-5,22E-dien-3β-ol

Synonyms: 

Molecular weight: 398.7

CAS: 474-67-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Plant Biology

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