A positive allosteric modulator of the M1 mAChR; dose-dependently reduces the concentration of acetylcholine required to activate M1; the effective range for potentiation is 0.1 to 100 μM with 3 nM acetylcholine; restores impairment in reversal learning in a mouse model of Alzheimer’s disease

BQCA – 5 mg

Brand:
Cayman
CAS:
338747-41-4
Storage:
-20
UN-No:
Non-Hazardous - /

BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR), as it dose-dependently reduces the concentration of acetylcholine required to activate the M1 receptor.{25275} The effective range for potentiation of M1 in cells by BQCA is 0.1 to 100 μM with an inflection point value of 845 nM when 3 nM acetylcholine is used.{25275} BQCA displays no potentiation, agonism, or antagonism at other mAChRs at concentrations up to 100 μM.{25275} It has excellent brain penetration and increases the firing rate of medial prefrontal cortex neurons in vivo in rats.{25277} BQCA prevents scopolamine-induced memory deficits in both contextual fear conditioning and a spontaneous alternation task in mice.{25275,25278} It also restores impairment in reversal learning in a mouse model of Alzheimer’s disease and improves memory performance in rats.{25277,25279}  

 

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Description

A positive allosteric modulator of the M1 mAChR; dose-dependently reduces the concentration of acetylcholine required to activate M1; the effective range for potentiation is 0.1 to 100 μM with 3 nM acetylcholine; restores impairment in reversal learning in a mouse model of Alzheimer’s disease

Formal name: 1,4-dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-3-quinolinecarboxylic acid

Synonyms: 

Molecular weight: 309.3

CAS: 338747-41-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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