An inhibitor of several different PTPs

bpV(phen) (potassium hydrate) – 5 mg

Brand:
Cayman
CAS:
171202-16-7
Storage:
-20
UN-No:
Non-Hazardous - /

bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM).{22161,22177} It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM).{22177,22160} At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5’-phosphatase-2.{22158} Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.{22162,22159,22157}  

 

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Description

An inhibitor of several different PTPs, with selectivity for PTEN (IC50 = 38 nM); also inhibits PTP-β (IC50 = 343 nM), PTP-1β (IC50 = 920 nM), and SHIP-2; activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.

Formal name: (PB-7-23-111’1’3)-oxodiperoxy(1,10-phenanthroline-κN1,κN10)-vanadate(1-), potassium trihydrate

Synonyms:  Bisperoxovanadium(phen)|Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V)

Molecular weight: 404.3

CAS: 171202-16-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling

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