A bpV compound that selectively inhibits PTEN (IC50 = 14 nM); also inhibits the vascular endothelial PTP

bpV(HOpic) (potassium salt) – 5 mg

Brand:
Cayman
CAS:
722494-26-0
Storage:
-20
UN-No:
Non-Hazardous - /

bpV(HOpic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 14 nM).{22177} It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 4.9 μM), and PTP-1βB (IC50 = 25.3 μM).{22177} At 15 μM, bpV(HOpic) has been shown to protect against stimulated ischemia-reperfusion injury in vitro by decreasing apoptosis and improving cell viability through the upregulation of the PI3K/Akt/eNOS/ERK prosurvival pathway.{22541}  

 

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Description

A bpV compound that selectively inhibits PTEN (IC50 = 14 nM); also inhibits the vascular endothelial PTP, PTP-β (IC50 = 4.9 μM), and PTP-1βB (IC50 = 25.3 μM) with reduced potency

Formal name: (5-hydroxy-2-pyridinecarboxylato-κN1,κO2)oxodiperoxy-vanadate(2-), dipotassium

Synonyms:  Bisperoxovanadium(HOpic)

Molecular weight: 347.2

CAS: 722494-26-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling

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