A linear imidazoquinazoline that potently and selectively inhibits the tyrosine kinase activity of EGFR (IC50 = 8 pM)

BPIQ-II (hydrochloride) – 500 µg

Brand:
Cayman
CAS:
171179-37-6
Storage:
-20
UN-No:
Non-Hazardous - /

BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM).{28434} It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.{28434}  

 

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Description

A linear imidazoquinazoline that potently and selectively inhibits the tyrosine kinase activity of EGFR (IC50 = 8 pM)

Formal name: N-(3-bromophenyl)-3H-imidazo[4,5-g]quinazolin-8-amine, monohydrochloride

Synonyms:  PD 158294

Molecular weight: 376.6

CAS: 171179-37-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling

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