A bacterial secondary metabolite which displays potent antiangiogenic activity

Borrelidin – 1 mg

Brand:
Cayman
CAS:
7184-60-3
Storage:
-20
UN-No:
Non-Hazardous - /

Borrelidin is a secondary metabolite produced by Streptomyces and other bacteria. It displays potent antiangiogenic activity, preventing tube formation in rat aorta explants (IC50 = 0.8 nM) and inducing apoptosis in endothelial cells.{22549,22545} Borrelidin also alters the splicing of VEGF mRNA, producing an antiangiogenic isoform of the growth factor.{22550} It has long been known as a powerful inhibitor of both eukaryotic and bacterial threonyl tRNA synthetase.{22547} Borrelidin is also an effective anti-malarial drug, as it kills P. falciparum with an IC50 value of 1.8 nM.{22546} At higher doses, it inhibits cyclin-dependent kinase in yeast (IC50 = 24 μM), resulting in growth arrest in the G1 phase.{22548}  

 

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Description

A bacterial secondary metabolite which displays potent antiangiogenic activity, preventing tube formation in rat aorta explants (IC50 = 0.8 nM) and inducing apoptosis in endothelial cells; powerful inhibitor of both eukaryotic and bacterial threonyl tRNA synthetase; effective anti-malarial drug

Formal name: (1R)-2R-[7-cyano-8R,16S-dihydroxy-9S,11R,13S,15S-tetramethyl-18-oxooxacyclooctadeca-4E,6Z-dien-2S-yl]-cyclopentanecarboxylic acid

Synonyms:  NSC 216128|Treponemycin

Molecular weight: 489.6

CAS: 7184-60-3

Purity: ≥98%

Formulation: A powder

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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