A bicyclic monoterpene with diverse biological activities; a positive allosteric modulator of α1β2γ2L subunit-containing GABAA receptors (EC50 = 248 μM for human recombinant receptors); dose-dependently increases the paw withdrawal threshold following segmental spinal nerve ligation surgery or intraplantar injection of CFA in mouse paw; inhibits increases in ROS levels and cytotoxicity at 100 μM in SH-SY5Y neuroblastoma cells incubated with Aβ42; inhibits the growth of Gram-positive and Gram-negative bacteria in vitro

(+)-Borneol – 1 g

Brand:
Cayman
CAS:
464-43-7
Storage:
-20
UN-No:
De Minimis - 1312 / 4.1

(+)-Borneol is a bicyclic monoterpene and a stereoisomer of (–)-borneol (Item No. 23468) that has been found in various plants, including S. tomentosa, and has diverse biological activities including analgesic, neuroprotective, antioxidant, and antimicrobial properties.{36773,36860,36861,36862} (+)-Borneol is a positive allosteric modulator of α1β2γ2L subunit-containing GABAA receptors (EC50 = 248 μM for human recombinant receptors).{36773} It dose-dependently increases the paw withdrawal threshold following segmental spinal nerve ligation surgery or intraplantar injection of complete Freund’s adjuvant (CFA) in mouse paw.{36860} (+)-Borneol (100 μM) inhibits increases in reactive oxygen species (ROS) levels and cytotoxicity in SH-SY5Y neuroblastoma cells incubated with amyloid-β (1-42) (Aβ42; Item No. 20574).{36861} It also inhibits the growth of Gram-positive and Gram-negative bacteria in vitro, including E. coli, S. aureus, P. aeruginosa, P. vulgaris, and S. typhimurium (MICs = 125-250 μg/mL).{36862} Formulations containing (+)-borneol have been used as fragrance ingredients.  

 

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SKU: 23467 - 1 g Category:

Description

A bicyclic monoterpene with diverse biological activities; a positive allosteric modulator of α1β2γ2L subunit-containing GABAA receptors (EC50 = 248 μM for human recombinant receptors); dose-dependently increases the paw withdrawal threshold following segmental spinal nerve ligation surgery or intraplantar injection of CFA in mouse paw; inhibits increases in ROS levels and cytotoxicity at 100 μM in SH-SY5Y neuroblastoma cells incubated with Aβ42; inhibits the growth of Gram-positive and Gram-negative bacteria in vitro, including E. coli, S. aureus, P. aeruginosa, P. vulgaris, and S. typhimurium (MICs = 125-250 μg/mL)

Formal name: (1R,2S,4R)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol

Synonyms:  (+)-endo-Borneol|(1R)-(+)-Borneol|D-Borneol

Molecular weight: 154.3

CAS: 464-43-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses||Research Area|Neuroscience|Neuroprotection||Research Area|Neuroscience|Pain Research

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