An NS3/4A protease inhibitor (Ki = 14 nM for the HCV genotype 1b enzyme); inhibits HCV replication in Huh7 cells (EC50 = 200 nM); inhibits SARS-CoV-2 Mpro (Ki = 1.8 µM); reduces cytopathic effects of SARS-CoV-2 in Vero cells (EC50 = 1.31 µM)

Boceprevir – 10 mg

Brand:
Cayman
CAS:
394730-60-0
Storage:
-20
UN-No:
Non-Hazardous - /

Boceprevir is an inhibitor of hepatitis C virus (HCV) non-structural protease 3/4A (NS3/4A; Ki = 14 nM for the HCV genotype 1b enzyme).{30614} Boceprevir inhibits HCV replication in Huh7 cells (EC50 = 200 nM).{36164} It also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro; Ki = 1.8 µM) and reduces cytopathic effects of SARS-CoV-2 in Vero cells (EC50 = 1.31 µM).{58053} Formulations containing boceprevir have been used in the treatment of HCV.  

 

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Description

An NS3/4A protease inhibitor (Ki = 14 nM for the HCV genotype 1b enzyme); inhibits HCV replication in Huh7 cells (EC50 = 200 nM); inhibits SARS-CoV-2 Mpro (Ki = 1.8 µM); reduces cytopathic effects of SARS-CoV-2 in Vero cells (EC50 = 1.31 µM)

Formal name: (1R,2S,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-3-azabicyclo[3.1.0]hexane-2-carboxamide

Synonyms:  Victrelis

Molecular weight: 519.7

CAS: 394730-60-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Immunology & Inflammation|Pulmonary Diseases|COVID-19||Research Area|Infectious Disease|Viral Diseases|Coronaviruses||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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