An α2C-and α1D-adrenoceptor antagonist (pKis = 6.54 and 8.2

BMY 7378 – 100 mg

Brand:
Cayman
CAS:
21102-95-4
Storage:
-20
UN-No:
Non-Hazardous - /

BMY 7378 is an antagonist of the α2C-adrenoceptor and α1D-adrenoceptor with pKi values of 6.54 and 8.2, respectively, that has been used in functional systems to assess the contribution of these receptors in vascular smooth muscle contraction.{33564,33563} It also acts as a partial agonist at the serotonin 5-HT1A receptor with a pKi value of 8.3.{33564}  

 

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Description

An α2C-and α1D-adrenoceptor antagonist (pKis = 6.54 and 8.2, respectively) and 5-HT1A partial agonist (pKi = 8.3)

Formal name: 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione, dihydrochloride

Synonyms: 

Molecular weight: 458.4

CAS: 21102-95-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Neuroscience

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