A potent and selective inhibitor of JAK2 (IC50s = 1

BMS-911543 – 25 mg

Brand:
Cayman
CAS:
1271022-90-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

BMS-911543 is a potent, selective ATP-competitive inhibitor of Janus kinase 2 (JAK2) that exhibits IC50 values of 1, 356, 73, and 66 nM for JAK2, JAK1, JAK3, and TYK2, respectively.{33764} It exhibits antiproliferative activity in a variety of cell lines engineered to express the JAK2V617F activating mutation (IC50s = 60-70 nM).{33764,33765} BMS-911543 exhibited limited activity in a mouse model of JAK2V617F-driven myeloproliferative neoplasm.{33766}  

 

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Description

A potent and selective inhibitor of JAK2 (IC50s = 1, 356, 73, and 66 nM for JAK2, JAK1, JAK3, and TYK2, respectively); exhibits antiproliferative activity in cell lines engineered to express the JAK2V617F activating mutation (IC50s = 60-70 nM)

Formal name: N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1,6-dihydro-1-methyl-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

Synonyms: 

Molecular weight: 432.5

CAS: 1271022-90-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|JAK Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cell Biology|Cell Signaling|JAK Signaling

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