An inhibitor of c-Met and VEGFR2 (IC50s = 1.7 and 15 nM

BMS 794833 – 5 mg

Brand:
Cayman
CAS:
1174046-72-0
Storage:
-20
UN-No:
De Minimis - 3077 / 9

BMS 794833 is an inhibitor of c-Met and VEGF receptor 2 (VEGFR2) with IC50 values of 1.7 and 15 nM, respectively, that also inhibits Axl, Flt3, and Ron.{42608,42609} It inhibits proliferation of GTL-16 gastric carcinoma cells (IC50 = 39 nM) and induces tumor statsis in GTL-16 and U87 mouse xenograft models when administered at a dose of 25 mg/kg.{42608}  

 

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SKU: 26180 - 5 mg Category:

Description

An inhibitor of c-Met and VEGFR2 (IC50s = 1.7 and 15 nM, respectively); inhibits proliferation of GTL-16 gastric carcinoma cells (IC50 = 39 nM); induces tumor stasis in GTL-16 and U87 mouse xenograft models at 25 mg/kg

Formal name: N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-pyridinecarboxamide

Synonyms: 

Molecular weight: 468.8

CAS: 1174046-72-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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