A partial agonist of LXRα and LXRβ (Kis = 68 and 14 nM

BMS 779788 – 10 mg

Brand:
Cayman
CAS:
918348-67-1
Storage:
-20
UN-No:
Non-Hazardous - /

BMS 779788 is a partial agonist of liver X receptor α (LXRα) and LXRβ (Kis = 68 and 14 nM, respectively, in a radioligand binding assay).{45493} It activates LXRα and LXRβ with EC50 values of 230 and 250 nM, respectively, in a transactivation assay. BMS 779788 increases expression of ATP-binding cassette transporter (ABCA1) in HeLa cells and isolated human and mouse whole blood (EC50s = 33, 1,200, and 120 nM, respectively). It also increases expression of Abca1 and Abcg2 in isolated mouse blood cells but does not increase plasma or hepatic triglycerides when administered at a dose of 10 mg/kg.  

 

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SKU: 27339 - 10 mg Category:

Description

A partial agonist of LXRα and LXRβ (Kis = 68 and 14 nM, respectively, in a radioligand binding assay); activates LXRα and LXRβ with EC50 values of 230 and 250 nM, respectively, in a transactivation assay increases expression of ABCA1 in HeLa cells and isolated human and mouse whole blood (EC50s = 33, 1,200, and 120 nM, respectively); increases expression of Abca1 and Abcg2 in mouse blood cells but does not increase plasma or hepatic triglycerides at 10 mg/kg

Formal name: 2-[1-(2-chlorophenyl)-1-methylethyl]-α,α-dimethyl-1-[3′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]-1H-imidazole-4-methanol

Synonyms: 

Molecular weight: 509.1

CAS: 918348-67-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs

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