An inhibitor of the Met kinase family (IC50s = 1.8

BMS-777607 – 10 mg

Brand:
Cayman
CAS:
1025720-94-8
Storage:
-20
UN-No:
Non-Hazardous - /

BMS-777607 is an inhibitor of the Met kinase family. It inhibits Ron, Met, Tyro-3, and AxI with IC50 values of 1.8, 3.9, 4.3, and 1.1 nM, respectively.{29883} At higher concentrations it is reported to inhibit Mer, FLT3, Aurora B, Lck, and VEGFR2 (IC50s = 14, 16, 78, 120, and 180 nM, respectively).{29883} In cancer cells, BMS-777607 induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis.{29883,29882} In tumor xenograft models, BMS-777607 at 50 mg/kg/mouse inhibits the growth of tumor cells expressing Met/Ron.{29883}  

 

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Description

An inhibitor of the Met kinase family (IC50s = 1.8, 3.9, 4.3, and 1.1 nM, respectively for Ron, Met, Tyro-3, and AxI); also inhibits Mer, FLT3, Aurora B, Lck, and VEGFR2 at higher concentrations (IC50s = 14, 16, 78, 120, and 180 nM, respectively); induces polyploidy with multiple sets of chromosomes, as well as suppresses metastasis in cancer cells

Formal name: N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide

Synonyms:  BMS-817378

Molecular weight: 512.9

CAS: 1025720-94-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Aurora Signaling||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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