A potent inhibitor of LIMK1 and LIMK2 (IC50s = 7 and 8 nM

BMS-5 – 5 mg

Brand:
Cayman
CAS:
1338247-35-0
Storage:
-20
UN-No:
Non-Hazardous - /

BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively.{32445} LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin.{32443,32444} This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin.  

 

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Description

A potent inhibitor of LIMK1 and LIMK2 (IC50s = 7 and 8 nM, respectively)

Formal name: N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl-propanamide

Synonyms:  LIM Kinase Inhibitor I|LIMKi 3

Molecular weight: 431.3

CAS: 1338247-35-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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