A pan-RAR inverse agonist that blocks RARα activity with an IC50 value of 114 nM; prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions

BMS 493 – 5 mg

Brand:
Cayman
CAS:
215030-90-3
Storage:
-20
UN-No:
Non-Hazardous - /

Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation.{20155,20156} BMS 493 is a pan-RAR inverse agonist that blocks RARα activity with an IC50 value of 114 nM.{30013,30014} In all RAR types (RARα, RARβ, and RARγ), BMS493 prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions.{30016,28461} BMS 493 has been used to elucidate the critical roles of RARs in development and immune response.{30013,30017,30012,30015}  

 

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Description

A pan-RAR inverse agonist that blocks RARα activity with an IC50 value of 114 nM; prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions

Formal name: 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic acid

Synonyms:  BMS 204493

Molecular weight: 404.5

CAS: 215030-90-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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