A BKCa channel activator; increases BKCa currents in X. laevis oocytes expressing human BKCa; decreases electrically induced pEPSPs in vitro in CA1 rat neurons and in anesthetized rats from 0.005-1 mg/kg; reduces infarct volume in an MCAO-induced rat model of ischemic stroke at 0.001 and 0.3 mg/kg; decreases edema in the ipsilateral hippocampus

BMS 204352 – 5 mg

Brand:
Cayman
CAS:
187523-35-9
Storage:
-20
UN-No:
Non-Hazardous - /

BMS 204352 is an activator of large-conductance calcium-activated potassium (BKCa) channels that increases BKCa currents in X. laevis oocytes expressing human BKCa in a calcium- and concentration-dependent manner.{48708} It decreases electrically induced population excitatory postsynaptic potentials (pEPSPs) in vitro in CA1 rat neurons and in anesthetized rats when administered at doses ranging from 0.005 to 1 mg/kg. BMS 204352 (0.001 and 0.3 mg/kg) reduces infarct volume in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO). It decreases edema in the ipsilateral hippocampus, thalamus, and adjacent cortex and time to find the platform in the Morris water maze in a rat model of fluid percussion-induced traumatic brain injury (TBI).{48709} BMS 204352 also reverses cortical hyperexcitability and reduces hyperactivity and grooming behaviors in the FmrI-/- mouse model of Fragile X syndrome.{48710} Formulations containing BMS 204352 have been used in the treatment of ischemic stroke.  

 

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Description

A BKCa channel activator; increases BKCa currents in X. laevis oocytes expressing human BKCa; decreases electrically induced pEPSPs in vitro in CA1 rat neurons and in anesthetized rats from 0.005-1 mg/kg; reduces infarct volume in an MCAO-induced rat model of ischemic stroke at 0.001 and 0.3 mg/kg; decreases edema in the ipsilateral hippocampus, thalamus, and adjacent cortex and time to find the platform in the Morris water maze in a rat model of fluid percussion-induced TBI; reverses cortical hyperexcitability and reduces hyperactivity and grooming behaviors in the FmrI-/- mouse model of Fragile X syndrome

Formal name: (3S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one

Synonyms:  (+)-BMS 204352

Molecular weight: 359.7

CAS: 187523-35-9

Purity: ≥98%

Formulation: A crystalline solid

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