A neutral RARα-selective antagonist (Ki = 2.5 nM); antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding

BMS 195614 – 5 mg

Brand:
Cayman
CAS:
182135-66-6
Storage:
-20
UN-No:
Non-Hazardous - /

BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM).{28460} It antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding.{28461}  

 

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Description

A neutral RARα-selective antagonist (Ki = 2.5 nM); antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding

Formal name: 4-[[[5,6-dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]-benzoic acid

Synonyms:  BMS 614

Molecular weight: 448.5

CAS: 182135-66-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs||Research Area|Epigenetics, Transcription, & Translation

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