Bleomycin A5 is one of a family of glycopeptide antibiotics first isolated from S. verticillus. As a family, the bleomycins consist of carbohydrate and metal binding domains joined to a variable C-terminal tail through a linker domain.{21617,32411} The metal binding domain and C-terminal tail mediate DNA and RNA binding that, in the presence of oxygen, generates free radicals leading to nucleic acid cleavage.{21617,32411} Bleomycin A5 has a C-terminal that mimics polyamines, facilitating its import into cells via the carnitine transporter SLC22A16.{29262} Cells expressing this transporter are ~300-fold more sensitive to bleomycin A5 than cells lacking this transporter, suggesting that cancer cells that overexpress SCL22A16 might be selectively targeted by this form of bleomycin.{29262}
Available on backorder
A form of bleomycin with a C-terminal that mimics polyamines, facilitating its import into cells via the carnitine transporter SLC22A16, which increases its cytotoxicity
Formal name: N1-[3-[(4-aminobutyl)amino]propyl]-bleomycinamide, hydrochloride
Synonyms: Pingyangmycin
Molecular weight: 1,440.60
CAS: 55658-47-4
Purity: ≥85%
Formulation: A powder
Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cell Biology|Mitochondrial Biology
1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
Available on backorder
The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
Available on backorder
The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
Available on backorder
The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
Available on backorder