(+)-Blebbistatin – 5 mg

Brand:
Cayman
CAS:
1177356-70-5
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-Blebbistatin is the inactive enantiomer of (–)-blebbistatin (Item No. 13013), which is a selective inhibitor of non-muscle myosin II ATPases.{16452,17037} Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.{17038,24037} (R)-nitro-Blebbistatin (Item No. 9001935) is a more stable form of (+)-blebbistatin.{16725} The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (R)-nitro-Blebbistatin has the same stereochemistry as the inactive (+)-blebbistatin enantiomer.  

 

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Description

An inactive enantiomer of (–)-blebbistatin; (R)-nitro-blebbistatin is a more stable form of (+)-blebbistatin,


Formal name: 1,2,3,3a-tetrahydro-3aR-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one

Synonyms:  (R)-Blebbistatin

Molecular weight: 292.3

CAS: 1177356-70-5

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cytoskeleton & Motor Proteins