A potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM

BIX02189 – 10 mg

Brand:
Cayman
CAS:
1265916-41-3
Storage:
-20
UN-No:
Non-Hazardous - /

MEK5, also known as MAP2K5, phosphorylates ERK5 (MAPK7) in signaling pathways involved in stress-induced apoptosis, neuronal survival, cardiac development, and angiogenesis.{15424,27915} BIX02189 is a potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM, respectively), preventing transcriptional activation of the downstream target MEF2C.{27914} It minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2.{27914} BIX02189 blocks sorbitol-induced phosphorylation of ERK5, without affecting phosphorylation of ERK1/2, in HeLa cells.{27914} It has been used to investigate the roles of MEK5/ERK5 signaling in nerve growth factor-mediated neurite outgrowth and myeloid cell differentiation.{27915,27913}  

 

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A potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM, respectively); minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2; blocks sorbitol-induced phosphorylation of ERK5, without affecting phosphorylation of ERK1/2, in HeLa cells

Formal name: (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide

Synonyms: 

Molecular weight: 440.5

CAS: 1265916-41-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Heart||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Neuroscience

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