A thrombin inhibitor (Kis = 2.56 and 1.84 nM for α- and ζ-thrombin

Bivalirudin – 25 mg

Brand:
Cayman
CAS:
128270-60-0
Storage:
-20
UN-No:
Non-Hazardous - /

Bivalirudin is an inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.{36230} It is selective for α- and ζ-thrombin, lacking activity at trypsin and γ-thrombin, which lacks clotting activity, at a >1,000-fold excess of bivalirudin. Bivalirudin inhibits α-thrombin-stimulated activation of the clotting factors Factor X, Factor V, and prothrombin in contact-activated plasma at a concentration of 0.1 μM.{36231} Administration of bivalirudin (0.5-1.5 mg/kg, i.v.) reduces platelet deposition in a rat carotid endarterectomy model in a dose-dependent manner.{36232} Formulations containing bivalirudin have been used to prevent ischemic events during angioplasty for thrombus-containing lesions.{36233}  

 

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SKU: 23035 - 25 mg Category:

Description

A thrombin inhibitor (Kis = 2.56 and 1.84 nM for α- and ζ-thrombin, respectively); selective for α- and ζ-thrombin, lacking activity at trypsin and γ-thrombin at a >1,000-fold excess; inhibits α-thrombin-stimulated activation of the clotting factors Factor X, Factor V, and prothrombin in contact-activated plasma; reduces platelet deposition in a rat carotid endarterectomy model in a dose-dependent manner

Formal name: D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucine

Synonyms: 

Molecular weight: 2,180.30

CAS: 128270-60-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Research Area|Cardiovascular System|Blood|Acute Phase Reactants||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Serum Proteins||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Heart

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