An anthelmintic drug; inhibits host caspases

Bithionol – 25 g

Brand:
Cayman
CAS:
97-18-7
Storage:
22
UN-No:
Limited Quantity - 2811 / 6.1

Bithionol is an anthelmintic drug. Formulations containing bithionol have demonstrated efficacy against cestodes and trematodes, as well as other parasitic worms.{34401,34402,34403} Bithionol inhibits host caspases, including caspases-1, -3, -6, -7, and -9, which act as hub proteins that mediate the lethality of multiple pathogenic agents.{34404} By blocking host caspases, bithionol reduces the detrimental effects of anthrax lethal toxin, diphtheria toxin, cholera toxin, P. aeruginosa exotoxin A, Botulinum neurotoxin, ricin, and Zika virus.{34404} Bithionol also inhibits NF-κB activation by blocking phosphorylation of IκBα (IC50 = 15.8 µM in a reporter gene assay).{31081}  

 

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Description

An anthelmintic drug; inhibits host caspases, including caspases-1, -3, -6, -7, and -9, which mediate the lethality of multiple pathogenic agents

Formal name: 2,2′-thiobis[4,6-dichloro-phenol]

Synonyms:  CP 3438|NSC 47129|NSC 9872

Molecular weight: 356.1

CAS: 97-18-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Cholera||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Infectious Disease|Viral Diseases|Zika

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