A cell permeable inhibitor of PKC with IC50 values reported to range from 0.10 to 0.55 µM; designed to be more discriminative than its parent compound

Bisindolylmaleimide IV – 1 mg

Brand:
Cayman
CAS:
119139-23-0
Storage:
-20
UN-No:
Non-Hazardous - /

Bisindolylmaleimide IV (BIM IV) is a cell permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 µM.{17276,17275,17277,17278} BIM IV was designed to be more discriminative than its parent compound, the non-selective PKC inhibitor, staurosporine (Item No. 81590). However, BIM IV also inhibits protein kinase A with IC50 values ranging from 2 to 11.8 µM.{17276,17275}  

 

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Description

A cell permeable inhibitor of PKC with IC50 values reported to range from 0.10 to 0.55 µM; designed to be more discriminative than its parent compound, the non-selective PKC inhibitor, staurosporine (Catalog No. 81590); also inhibits protein kinase A with IC50 values ranging from 2 to 11.8 µM

Formal name: 3,4-di-1H-indol-3-yl-1H-pyrrole-2,5-dione

Synonyms:  Arcyriarubin A|BIM IV

Molecular weight: 327.3

CAS: 119139-23-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKA||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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