A general inhibitor of all PKC subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine; inhibits PDK1 (IC50 = 14 μM) and PKA (IC50 = 2.94 μM)

Bisindolylmaleimide II – 1 mg

Brand:
Cayman
CAS:
137592-45-1
Storage:
-20
UN-No:
Non-Hazardous - /

Bisindolylmaleimide II (BIM II) is a general inhibitor of all protein kinase C (PKC) subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine.{17276,17275} At 10 μM, BIM II inhibits 98% of PKCα kinase activity.{20731} Additionally, it inhibits PDK1 (IC50 = 14 μM), an important kinase in the insulin signaling pathway, and PKA (IC50 = 2.94 μM).{20731,20730} Studies of structure-activity relationships of BIM II in complex with PDK1 and PKA kinase binding domains has led to useful insights into kinase/ligand binding for the rational design of inhibitors as potential therapeutic agents.{20731,20730}  

 

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SKU: 11020 - 1 mg Category:

Description

A general inhibitor of all PKC subtypes with structural similarity to the nonspecific PKC inhibitor staurosporine; inhibits PDK1 (IC50 = 14 μM) and PKA (IC50 = 2.94 μM)

Formal name: 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione

Synonyms:  BIM II

Molecular weight: 438.5

CAS: 137592-45-1

Purity: ≥97% (isomer mixture)

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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