Bisacodyl is a prodrug form of the stimulant laxative desacetyl bisacodyl (Item No. 20928).{33529} It reduces the activity of Na+/K+-ATPases in isolated rat colon following administration in the drinking water at a concentration of 83 µM.{48734} Bisacodyl (20 mg/kg) decreases colonic aquaporin-3 levels and increases stool water content in rats, effects that are reversed by the COX inhibitor indomethacin (Item No. 70270).{33527} Formulations containing bisacodyl have been used in the treatment of constipation.
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A prodrug form of desacetyl bisacodyl; reduces the activity of Na+/K+-ATPases in isolated rat colon at 83 µM in the drinking water; decreases colonic aquaporin-3 levels and increases stool water content in rats at 20 mg/kg
Formal name: 4,4′-(2-pyridinylmethylene)bis-phenol, 1,1′-diacetate
Synonyms:
Molecular weight: 361.4
CAS: 603-50-9
Purity: ≥98%
Formulation: A crystalline solid
The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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