A tacrine dimer

bis(7)-Tacrine – 10 mg

Brand:
Cayman
CAS:
224445-12-9
Storage:
-20
UN-No:
Non-Hazardous - /

Tacrine is an amino acridine compound that inhibits acetylcholinesterase (AChE), and has been proposed as a clinical treatment for Alzheimer’s disease.{6603} bis(7)-Tacrine is a tacrine dimer, linked via a 7-carbon alkyl spacer. It inhibits AChE with an IC50 of 0.40 nM, making it more than 1,000 times more potent than tacrine.{12097} bis(7)-Tacrine also protects against hydrogen peroxide induced apoptosis in rat pheochromocytoma cells.{12095}  

 

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SKU: 10005836 - 10 mg Category:

Description

A tacrine dimer, linked via a 7-carbon alkyl spacer; inhibits AChE (IC50 = 0.40 nM), making it more than 1,000 times more potent than tacrine ;protects against hydrogen peroxide induced apoptosis in rat pheochromocytoma cells

Formal name: N,N’-bis(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine, dihydrochloride

Synonyms:  1,7-N-heptylene-bis-9,9′-amino-1,2,3,4-tetrahydro-acridine

Molecular weight: 565.6

CAS: 224445-12-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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