A substrate of biotinidase

(+)-Biotin 4-Amidobenzoic Acid (sodium salt) – 10 mg

Brand:
Cayman
CAS:
102418-74-6
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-Biotin 4-amidobenzoic acid is a substrate of biotinidase, which cleaves biotin amide to give biotin in vivo. Biotin is an essential coenzyme for certain carboxylases and is used to modify histones and regulate gene transcription.{32218} Biotinidase has key roles in intestinal absorption of biotin, the transport of biotin in plasma, and in the regulation of histone biotinylation.{32218} (+)-Biotin 4-amidobenzoic acid is hydrolyzed by biotinidase to release 4-aminobenzoic acid (PABA), which can be quantified by either fluorescent or colorimetric methods.{32216} This approach is used in biotinidase activity assays in newborn screening protocols to evaluate biotinidase deficiency.{32217}  

 

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Description

A substrate of biotinidase, releasing PABA, which can be quantified by either fluorescent or colorimetric methods

Formal name: 4-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-benzoic acid, monosodium salt

Synonyms:  (+)-Biotin PABA

Molecular weight: 385.4

CAS: 102418-74-6

Purity: ≥98%

Formulation: A crystalline solid

Application|Enzyme Activity||Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Epigenetics, Transcription, & Translation|Erasers

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