A phytoestrogen that can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity; activates PPARγ (EC50 = 19 µM) and increases the expression of PGC-1α; also inhibits FAAH (IC50 = 2.4 µM) and agonizes AhR (EC50 = 0.25 µM)

Biochanin A – 1 g

Brand:
Cayman
CAS:
491-80-5
Storage:
-20
UN-No:
Non-Hazardous - /

Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity.{12555,27057} Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein (Item No. 10005167), another phytoestrogen with diverse effects.{22968} Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC50 = 19 µM) and has also been shown to activate a PPARα promoter.{27056} Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis.{16120} Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 µM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 µM).{27055,27054}  

 

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Description

A phytoestrogen that can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity; activates PPARγ (EC50 = 19 µM) and increases the expression of PGC-1α; also inhibits FAAH (IC50 = 2.4 µM) and agonizes AhR (EC50 = 0.25 µM)

Formal name: 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  4’-methyl Genistein|5,7-dihydroxy-4′-Methoxyisoflavone|NSC 123538

Molecular weight: 284.3

CAS: 491-80-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area

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