A potent inhibitor of GSK3α/β (IC50 = 10 nM)

BIO-Acetoxime – 5 mg

Brand:
Cayman
CAS:
740841-15-0
Storage:
-20
UN-No:
Non-Hazardous - /

BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO (Item No. 13123).{17160,17161} It potently inhibits GSK3α/β (IC50 = 10 nM), with selectivity over Cdk5/p25, Cdk2/A, and Cdk1/B (IC50s = 2.4, 4.3, and 63 µM, respectively).{17160,17161} BIO-Acetoxime has been used to study the role of GSK3 in the Wnt/β-catenin pathway.{27753} It also suppresses the cytopathic effects of herpes viruses and reduces viral yields in human oral epithelial cells.{27754}  

 

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Description

A potent inhibitor of GSK3α/β (IC50 = 10 nM), with selectivity over Cdk5/p25, Cdk2/A, and Cdk1/B (IC50s = 2.4, 4.3, and 63 µM, respectively); suppresses the cytopathic effects of herpes viruses and reduces viral yields in human oral epithelial cells

Formal name: 3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-indol-2-one

Synonyms:  6-Bromoindirubin-3′-acetoxime|GSK3 Inhibitor X

Molecular weight: 398.2

CAS: 740841-15-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Wnt Signaling||Research Area|Infectious Disease|Viral Diseases|HSV||Research Area|Neuroscience

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