An inhibitor of Drosophila Aurora B kinase (Ki = 0.36 µM); specific for Drosophila B kinase

Binucleine 2 – 5 mg

Brand:
Cayman
CAS:
220088-42-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 µM), a kinase involved in cell division.{36242} It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 µM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 µM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.  

 

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SKU: 23367 - 5 mg Category:

Description

An inhibitor of Drosophila Aurora B kinase (Ki = 0.36 µM); specific for Drosophila B kinase, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 µM; induces mitotic and cytokinesis defects in Drosophila Kc167 cells; prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 µM

Formal name: N’-[1-(3-chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl]-N,N-dimethyl-methanimidamide

Synonyms: 

Molecular weight: 291.7

CAS: 220088-42-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|Aurora||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Signaling|Aurora Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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