An orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM) that inhibits ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM); efficacious in several xenograft tumor models in mice

Binimetinib – 100 mg

Brand:
Cayman
CAS:
606143-89-9
Storage:
-20
UN-No:
Non-Hazardous - /

Binimetinib is an orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM).{27962} It has been found to inhibit ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM).{27962} This compound is efficacious in several xenograft tumor models in mice, including those bearing K-Ras or B-RAF mutations, and has been characterized in clinical studies using patients with N-Ras melanoma, non-small cell lung cancer, or biliary tract cancer.{27962,27963,27940}  

 

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Description

An orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM) that inhibits ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM); efficacious in several xenograft tumor models in mice, including those bearing K-Ras or B-RAF mutations, as well as in clinical studies using patients with N-Ras melanoma, non-small cell lung cancer, or biliary tract cancer

Formal name: 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

Synonyms:  ​ARRY-438162|MEK162

Molecular weight: 441.2

CAS: 606143-89-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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