A pan-selectin inhibitor (IC50s = 88

Bimosiamose – 1 mg

Brand:
Cayman
CAS:
187269-40-5
Storage:
-20
UN-No:
Non-Hazardous - /

Bimosiamose is a pan-selectin inhibitor (IC50s = 88, 20, and 86 µM for E-, P-, and L-selectin, respectively).{52580} It reduces adhesion of HL-60 cells to E- and P-selectin when used at a concentration of 129 µM.{52581} In vivo, bimosiamose (200 mg/kg) reduces skin scaliness, induration, and erythema in a patient-derived xenograft mouse model of psoriasis. It decreases hepatic alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and myeloperoxidase (MPO) levels and reduces neutrophil infiltration in a rat model of severe hepatic ischemia-reperfusion injury.{52580} Bimosiamose also prevents nematode-induced late airway reactivity in sheep and reduces airway hyperresponsiveness in a mouse model of asthma.{52582}  

 

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Description

A pan-selectin inhibitor (IC50s = 88, 20, and 86 µM for E-, P-, and L-selectin, respectively); reduces adhesion of HL-60 cells to E- and P-selectin at 129 µM; reduces skin scaliness, induration, and erythema in a patient-derived xenograft mouse model of psoriasis at 200 mg/kg; decreases hepatic ALT, AST, LDH, and MPO levels and reduces neutrophil infiltration in a rat model of severe hepatic ischemia-reperfusion injury; prevents nematode-induced late airway reactivity in sheep and reduces airway hyperresponsiveness in a mouse model of asthma

Formal name: 3′,3′′′-(1,6-hexanediyl)bis[6′-(α-D-mannopyranosyloxy)-[1,1′-biphenyl]-3-acetic acid

Synonyms:  TBC 1269

Molecular weight: 862.9

CAS: 187269-40-5

Purity: ≥98%

Formulation: A crystalline solid

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