A potent

BIIB021 – 10 mg

Brand:
Cayman
CAS:
848695-25-0
Storage:
-20
UN-No:
Non-Hazardous - /

BIIB021 is a potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC50 = 38 nM), while up-regulating the expression of Hsp70 and Hsp27.{29827,29829} It is cytotoxic to cancer cells and, when administered orally to mice, inhibits growth of xenograft tumors.{29827,29829,29828} BIIB021 suppresses growth in various lymphoma cells but not in normal lymphocytes and induces apoptosis in a myelodysplastic syndrome cell line.{29826,29830,29828}  

 

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Description

A potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC50 = 38 nM), while up-regulating the expression of Hsp70 and Hsp27; cytotoxic to cancer cells and, when administered orally to mice, inhibits growth of xenograft tumors

Formal name: 6-chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine

Synonyms:  CNF2024

Molecular weight: 318.8

CAS: 848695-25-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer||Research Area|Cell Biology|Cellular Chaperones

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