An internal standard for the quantification of bicalutamide by GC- or LC-MS

Bicalutamide-d4 – 500 µg

Brand:
Cayman
CAS:
1185035-71-5
Storage:
4
UN-No:
Non-Hazardous - /

Bicalutamide-d4 is intended for use as an internal standard for the quantification of bicalutamide (Item No. 14250) by GC- or LC-MS. Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (Ki = 12.5 μM; IC50 = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones.{22431,22433} Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.{22432,22430}  

 

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Description

An internal standard for the quantification of bicalutamide by GC- or LC-MS,

Formal name: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl-2,3,5,6-d4)sulfonyl]-2-hydroxy-2-methyl-propanamide

Synonyms: 

Molecular weight: 434.4

CAS: 1185035-71-5

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens

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