Description
A broad-spectrum β-lactam antibiotic; active against aerobic and anaerobic, Gram-positive and Gram-negative bacteria, including clinical isolates of E. coli, oxacillin-sensitive S. aureus, B. fragilis, and Clostridium (MIC90s = 0.12, 0.12, 0.25, and 1 μg/ml, respectively); active against the rifampicin-susceptible H37Rv and rifampicin-resistant 115R and 124R M. tuberculosis strains (MICs = 2-4, 4-8, and 8-16 mg/L, respectively); decreases the number of lung CFUs in a mouse model of M. tuberculosis infection at 200 mg/kg
Formal name: 6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium, inner salt
Synonyms: CL 186815|LJC 10,627
Molecular weight: 350.4
CAS: 120410-24-4
Purity: ≥95%
Formulation: A crystalline solid