An inhibitor of FAAH (IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme); inhibits FAAH2

BIA 10-2474 – 5 mg

Brand:
Cayman
CAS:
1233855-46-3
Storage:
-20
UN-No:
Non-Hazardous - /

BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH; IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme).{40060} It also inhibits FAAH2, α/β-hydrolase domain-containing protein 6 (ABHD6), carboxylesterase 2 (CES2), and patatin-like phospholipase domain 6 (PNPLA6) with IC50 values of 0.4, 0.081, 2, and 11 μM, respectively. BIA 10-2474 alters expression of 161 lipid species, including FAAH substrates as well as other lipid classes, in human cortical neuron cultures indicating compound promiscuity. Formulations containing BIA 10-2474 were previously investigated clinically for the management of chronic pain but use was halted due to development of significant neurotoxicity.  

 

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SKU: 23157 - 5 mg Category:

Description

An inhibitor of FAAH (IC50 = 4.9 nM in HEK293T cells expressing the human recombinant enzyme); inhibits FAAH2, ABHD6, CES2, and PNPLA6 (IC50s = 0.4, 0.081, 2, and 11 μM, respectively); alters expression of 161 lipid species, including FAAH substrates as well as other lipid classes, in human cortical neuron cultures indicating compound promiscuity

Formal name: N-cyclohexyl-N-methyl-4-(1-oxido-3-pyridinyl)-1H-imidazole-1-carboxamide

Synonyms: 

Molecular weight: 300.4

CAS: 1233855-46-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids||Research Area|Neuroscience|Pain Research

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