A potent and selective BRD9 bromodomain inhibitor (Kd = 15.4 nM; IC50 = 19 nM) that less effectively inhibits the BRD7 bromodomain (IC50 = 117 nM); inhibits the growth of EOL-1 acute myeloid leukemia cells in vitro (EC50 = 1.4 µM)

BI-7273 – 25 mg

Brand:
Cayman
CAS:
1883429-21-7
Storage:
-20
UN-No:
Non-Hazardous - /

BI-7273 is a potent BRD9 bromodomain inhibitor (Kd = 15.4 nM; IC50 = 19 nM) that less effectively inhibits the functionally and structurally related BRD7 bromodomain (IC50 = 117 nM).{30788} It is without effect against the bromodomains of BRD2 and BRD4, as well as a panel of kinases. BI-7273 inhibits the growth of EOL-1 acute myeloid leukemia cells in vitro (EC50 = 1.4 µM).{30788}  

 

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Description

A potent and selective BRD9 bromodomain inhibitor (Kd = 15.4 nM; IC50 = 19 nM) that less effectively inhibits the BRD7 bromodomain (IC50 = 117 nM); inhibits the growth of EOL-1 acute myeloid leukemia cells in vitro (EC50 = 1.4 µM)

Formal name: 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one

Synonyms: 

Molecular weight: 353.4

CAS: 1883429-21-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains

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