An IKKβ inhibitor (IC50 = 380 nM); selective for IKKβ over insulin-like growth factor 1 (IGF1; IC50 = 7.6 μM) and over 100 kinases in a panel up to 10 μM; partially inhibits IL-1-stimulated activation of IKKε/TBK1 in vitro; inhibits TNF-α-dependent IkB degradation and expression of the proinflammatory cytokines IL-6

BI-605906 – 1 mg

Brand:
Cayman
CAS:
960293-88-3
Storage:
-20
UN-No:
Non-Hazardous - /

BI-605906 is an inhibitor of inhibitor of kappa B kinase subunit β (IKKβ; IC50 = 380 nM).{32502} It is selective for IKKβ over insulin-like growth factor 1 (IGF1; IC50 = 7.6 μM) and over 100 kinases in a panel up to 10 μM. BI-605906 partially inhibits IL-1-stimulated activation of IKKε/TBK1 in vitro. BI-605906 also inhibits TNF-α-dependent IkB degradation and expression of the proinflammatory cytokines IL-6, IL-1β, and C-X-C motif ligand 1/2 (CXCL1/2) without affecting lipogenic gene expression or glucose production in murine primary hepatocytes.{40150}  

 

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Description

An IKKβ inhibitor (IC50 = 380 nM); selective for IKKβ over insulin-like growth factor 1 (IGF1; IC50 = 7.6 μM) and over 100 kinases in a panel up to 10 μM; partially inhibits IL-1-stimulated activation of IKKε/TBK1 in vitro; inhibits TNF-α-dependent IkB degradation and expression of the proinflammatory cytokines IL-6, IL-1β, and CXCL1/2 without affecting lipogenic gene expression or glucose production in murine primary hepatocytes,

Formal name: 3-amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]-thieno[2,3-b]pyridine-2-carboxamide

Synonyms: 

Molecular weight: 432.5

CAS: 960293-88-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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