A small molecule antagonist of HNF4α that at 20 μM reduces endogenous insulin gene expression by as much as 50-fold in T6PNE cells; induces hepatic steatosis in vivo and is cyctotoxic to human hepatocellular carcinoma cell lines

BI-6015 – 50 mg

Brand:
Cayman
CAS:
93987-29-2
Storage:
-20
UN-No:
Non-Hazardous - /

Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor transcription factor that controls the expression of many genes including those involved in glucose and lipid homeostasis and maintenance of epithelial differentiation. BI-6015 is a small molecule antagonist of HNF4α that has been shown to repress the expression of known HNF4α target genes.{21357} At concentrations up to 20 μM, BI-6015 has been shown to reduce endogenous insulin gene expression by as much as 50-fold in T6PNE cells.{21357} The hepatocytes from livers of mice injected with 10 and 30 mg/kg BI-6015 exhibit marked, dose-dependent fat accumulation (steatosis).{21357} Additionally, at a daily dose of 30 mg/kg, BI-6015 induces apoptosis in a human hepatocellular carcinoma mouse model.{21357}  

 

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SKU: 12032 - 50 mg Category:

Description

A small molecule antagonist of HNF4α that at 20 μM reduces endogenous insulin gene expression by as much as 50-fold in T6PNE cells; induces hepatic steatosis in vivo and is cyctotoxic to human hepatocellular carcinoma cell lines

Formal name: 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole

Synonyms: 

Molecular weight: 331.3

CAS: 93987-29-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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