A triterpenoid; active against P. falciparum W2 clone (IC50 = 10.01 µM)

Betulonic Acid – 50 mg

Brand:
Cayman
CAS:
4481-62-3
Storage:
-20
UN-No:
Non-Hazardous - /

Betulonic acid is a triterpenoid that has been found in B. chinensis and has diverse biological activities, including antiparasitic, antiviral, and anticancer properties.{52273,52274,52275,52276} It is active against the chloroquine-resistant P. falciparum W2 clone (IC50 = 10.01 µM), as well as L. infantum and L. donovani promastigotes when used at a concentration of 50 µM.{52275,52274} Betulonic acid inhibits replication of herpes simplex virus I (HSV-I), echovirus 6, and the H7N1 strain of influenza A (EC50s = 0.9, 73.32, and 5.7 µM, respectively).{52276} It inhibits proliferation of MGC803, Bcap-37, MCF-7, PC3, and NIH3T3 cancer cells by 68.1, 44.9, 56.1, 52.4, and 22.1%, respectively, when used at a concentration of 20 µM.{52273}  

 

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Description

A triterpenoid; active against P. falciparum W2 clone (IC50 = 10.01 µM), as well as L. infantum and L. donovani promastigotes at 50 µM; inhibits replication of HSV-I, echovirus 6, and the H7N1 strain of influenza A (EC50s = 0.9, 73.32, and 5.7 µM, respectively); inhibits proliferation of MGC803, Bcap-37, MCF-7, PC3, and NIH3T3 cancer cells by 68.1, 44.9, 56.1, 52.4, and 22.1%, respectively, at 20 µM

Formal name: 3-oxo-lup-20(29)-en-28-oic acid

Synonyms:  Liquidambaric Acid|MJ347-RS|NSC 152534

Molecular weight: 454.7

CAS: 4481-62-3

Purity: ≥95%

Formulation: A crystalline solid

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