A muscarinic acetylcholine receptor agonist (IC50s = 1

Bethanechol (chloride) – 1 g

Brand:
Cayman
CAS:
590-63-6
Storage:
-20
UN-No:
Non-Hazardous - /

Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors.{40682} It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Item No. 15592) in isolated guinea pig small intestine (IC50 = 127 µM).{18340} Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 µM).{27105} It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 µg/kg.{40787} Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.  

 

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SKU: 23830 - 1 g Category:

Description

A muscarinic acetylcholine receptor agonist (IC50s = 1,837, 25, 631, 317, and 393 µM for M1-5, respectively); inhibits M2-mediated increases in cyclic AMP induced by isoproterenol in guinea pig small intestine (IC50 = 127 µM); increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 µM); induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats (60 µg/kg)

Formal name: 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium, monochloride

Synonyms:  (±)-Bethanechol|Carbamyl-β-methylcholine chloride|NSC 30783

Molecular weight: 196.7

CAS: 590-63-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area

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