A quaternary ammonium compound with diverse biological activities; has roles in osmoregulation and serves as a methyl donor in the conversion of homocysteine to methionine; reduces serum ALT and AST activity

Betaine – 250 g

Brand:
Cayman
CAS:
107-43-7
Storage:
-20
UN-No:
Non-Hazardous - /

Betaine is a quaternary ammonium compound with diverse biological activities.{47329,47330,47331} It has been found in spinach and can be acquired through the diet or formed via oxidation of betaine aldehyde (Item No. 17270) during choline metabolism in the liver and kidney.{47329,47332} Betaine has roles in osmoregulation and serves as a methyl donor in the conversion of homocysteine to methionine.{47329} Betaine (1.5% w/v in drinking water) reduces serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, increases serum HDL levels, decreases serum LDL levels, and reduces hepatic steatosis and inflammation in a mouse model of non-alcoholic fatty liver disease (NAFLD) induced by a methionine- and choline-deficient diet.{47330} It also reduces plasma levels of total homocysteine (tHcy), S-adenosylmethionine (AdoMet), S-adenosylhomocysteine (AdoHcy; Item No. 13603), and cystathionine, and attenuates hypercoagulation in a mouse model of homocystinuria.{47331} Formulations containing betaine have been used in the treatment of homocystinuria.  

 

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SKU: 26814 - 250 g Category:

Description

A quaternary ammonium compound with diverse biological activities; has roles in osmoregulation and serves as a methyl donor in the conversion of homocysteine to methionine; reduces serum ALT and AST activity, increases serum HDL levels, decreases serum LDL levels, and reduces hepatic steatosis and inflammation in a mouse model of NAFLD induced by a methionine- and choline-deficient diet at 1.5% w/v in drinking water; reduces plasma levels of tHcy, AdoMet, AdoHcy, and cystathionine and attenuates hypercoagulation in a mouse model of homocystinuria

Formal name: 1-carboxy-N,N,N-trimethyl-methanaminium, inner salt

Synonyms:  Glycine Betaine|N,N,N-Trimethylglycine

Molecular weight: 117.1

CAS: 107-43-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH

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